SCHEMBL8124667

SCHEMBL8124667

O=[N+]([O-])c1ccc2c(c1)C(OS(=O)(=O)C(F)(F)F)=NC(CF)(CF)O2

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 1/20 0.35
PDE4C Q08493 1/20 0.35
PDE4D Q08499 1/20 0.35
PTPRC P08575 3/20 0.33
S100A4 P26447 2/20 0.33
CA1 P00915 2/20 0.32
CA9 Q16790 2/20 0.32
CA2 P00918 1/20 0.32
CA5A P35218 1/20 0.32
CAPN9 O14815 1/20 0.32
CASP3 P42574 1/20 0.32
HSD11B1 P28845 2/20 0.31
AKR1B1 P15121 1/20 0.31
MEN1 O00255 3/20 0.31
KMT2A Q03164 3/20 0.31
ALDH1A1 P00352 2/20 0.31
CYP3A4 P08684 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8135352 0.77 PDE4A (0.34) PDE4APDE4CPDE4DPTPRCS100A4
SCHEMBL3029267 0.77 PDE4A (0.37) PDE4APDE4CPDE4DPTPRCS100A4
SCHEMBL8121276 0.76 HSD17B10 (0.37) PTPRCS100A4CA1CA9CA2
SCHEMBL8131394 0.74
SCHEMBL8120919 0.73 PDE4A (0.37) PDE4APDE4CPDE4DPTPRCS100A4
SCHEMBL8128176 0.69 MAPT (0.40) PDE4DMEN1KMT2AALDH1A1CYP3A4
SCHEMBL5827934 0.68 PTPRC (0.36) PDE4APDE4CPDE4DPTPRCS100A4
SCHEMBL8129019 0.67 KMT2A (0.37) MEN1KMT2AALDH1A1CYP3A4TDP1
SCHEMBL21878597 0.65 CYP3A4 (0.44) PDE4APDE4CPDE4DPTPRCS100A4
SCHEMBL8771651 0.65 PTPRC (0.38) PDE4APDE4CPDE4DPTPRCS100A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0655448-B1 BENZOPYRAN AND BENZOXAZINE DERIVATIVES CHUGAI PHARMACEUTICAL CO LTD (JP) 2000-04-12 EP disclosed
US-5977167-A Benzopyran and benzoxazine derivatives CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1999-11-02 US disclosed
US-5874446-A ANTIASTHMATICS, ANTIEPILEPSY AGENTS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1999-02-23 US disclosed
US-5614633-A POTASSIUM CHANNEL ACTIVATOR CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-03-25 US disclosed
EP-0655448-A1 BENZOPYRAN AND BENZOXAZINE DERIVATIVES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1995-05-31 EP disclosed