Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.78 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8133668 | 0.86 | EGFR (0.70) | EGFRERBB2ABCG2 | |
| SCHEMBL8131609 | 0.86 | EGFR (0.67) | EGFRERBB2 | |
| SCHEMBL8126928 | 0.85 | EGFR (0.65) | EGFRERBB2 | |
| SCHEMBL6584548 | 0.81 | EGFR (0.77) | EGFRERBB2EPHB2MEN1KMT2A | |
| SCHEMBL5564456 | 0.79 | MAPK1 (0.82) | EGFRERBB2MEN1KMT2AABCG2 | |
| SCHEMBL12922145 | 0.79 | EGFR (0.81) | EGFRERBB2 | |
| SCHEMBL12012727 | 0.78 | EGFR (1.00) | EGFRERBB2ABCG2 | |
| SCHEMBL31060998 | 0.78 | EGFR (1.00) | EGFRERBB2ABCG2MAPK1 | |
| SCHEMBL1417740 | 0.78 | EGFR (1.00) | EGFRERBB2ABCG2MAPK1 | |
| SCHEMBL17113735 | 0.78 | EGFR (0.75) | EGFRERBB2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000039-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | American Cyanamid Company (US) | 2000-05-17 | — | — | EP | claimed |
| WO-1999009016-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-02-25 | — | — | WO | claimed |
| EP-1000039-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | American Cyanamid Company (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999009016-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-02-25 | — | — | WO | disclosed |