SCHEMBL8125486

SCHEMBL8125486

Cc1nc2c(N)nc3ccccc3c2n1CCCCNC(=O)c1ccc(C(OCCN(C)C)c2ccccc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.49
TLR8 Q9NR97 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8135971 0.89 TLR7 (0.52) TLR7TLR8
SCHEMBL8133004 0.87 TLR7 (0.44) TLR7TLR8
SCHEMBL8125963 0.86 TLR7 (0.45) TLR7TLR8
SCHEMBL3863678 0.84 TLR7 (0.60) TLR7TLR8
SCHEMBL8128022 0.84 TLR7 (0.44) TLR7TLR8
SCHEMBL22359227 0.83 TLR7 (0.56) TLR7TLR8
SCHEMBL3863771 0.83 TLR7 (0.61) TLR7TLR8
SCHEMBL3353953 0.82 TLR7 (0.53) TLR7TLR8
SCHEMBL6093743 0.81 TLR7 (0.50) TLR7TLR8
SCHEMBL3862418 0.81 TLR7 (0.60) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6069149-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS TERUMO KABUSHIKI KAISHA (JP) 2000-05-30 US disclosed
EP-0894797-A1 NOVEL AMIDE DERIVATIVES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF TERUMO KABUSHIKI KAISHA (JP) 1999-02-03 EP disclosed