Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.71 |
| ▸ | HTR1A | P08908 | 2/20 | 0.71 |
| ▸ | HTR1D | P28221 | 2/20 | 0.71 |
| ▸ | HTR1B | P28222 | 2/20 | 0.71 |
| ▸ | HTR2C | P28335 | 11/20 | 0.60 |
| ▸ | HTR2B | P41595 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 9/20 | 0.53 |
| ▸ | WDR5 | P61964 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8156195 | 0.90 | SLC2A1 (0.71) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8124544 | 0.90 | HTR2C (0.74) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8117432 | 0.88 | SLC2A1 (0.66) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8131066 | 0.88 | SLC2A1 (0.71) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8134464 | 0.88 | SLC2A1 (0.69) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8131252 | 0.88 | SLC2A1 (0.70) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8135013 | 0.87 | SLC2A1 (0.68) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8151359 | 0.87 | SLC2A1 (0.62) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8135507 | 0.87 | SLC2A1 (0.69) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8126878 | 0.86 | SLC2A1 (0.68) | SLC2A1HTR1AHTR1DHTR1BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | claimed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | claimed |
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |