Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 5/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128554 | 1.00 | HPGD (0.41) | HPGDALDH1A1MAPTGAAHSD17B10 | |
| SCHEMBL8127802 | 0.82 | HPGD (0.46) | HPGDALDH1A1MAPTGAAHSD17B10 | |
| SCHEMBL8127796 | 0.82 | HPGD (0.46) | HPGDALDH1A1MAPTGAAHSD17B10 | |
| SCHEMBL8128285 | 0.82 | CA12 (0.41) | HPGDALDH1A1MAPTGAALMNA | |
| SCHEMBL8128073 | 0.73 | HPGD (0.65) | HPGDALDH1A1MAPTGAAHSD17B10 | |
| SCHEMBL8128077 | 0.73 | HPGD (0.65) | HPGDALDH1A1MAPTGAAHSD17B10 | |
| SCHEMBL8118733 | 0.72 | KAT6A (0.37) | HPGDALDH1A1MAPTGAALMNA | |
| SCHEMBL26335081 | 0.71 | MAPT (0.49) | HPGDALDH1A1MAPTGAALMNA | |
| SCHEMBL24959630 | 0.70 | CA9 (0.37) | MAPTSMN1; SMN2CA12CA1CA2 | |
| SCHEMBL4733374 | 0.70 | MEN1 (0.39) | HPGDALDH1A1MAPTGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124343-A | Substituted phenyl compounds with a substituent having a thienyl ring | RHONE-POULENC RORER LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0805802-B1 | SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS | RHONE POULENC RORER LTD (GB) | 2000-08-16 | — | — | EP | disclosed |
| US-6048893-A | Substituted phenyl compounds with a substituent having A 1,3-benzodioxole ring | RHONE-POULENC RORER LIMITED (GB) | 2000-04-11 | — | — | US | disclosed |
| EP-0805802-A1 | SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS | RHONE-POULENC RORER LIMITED (GB) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022978-A1 | SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS | RHONE POULENC RORER LIMITED (GB) | 1996-08-01 | — | — | WO | disclosed |