Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.37 |
| ▸ | CACNG8 | Q8WXS5 | 6/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125580 | 0.81 | RHEB (0.39) | RHEBP2RX7HTR1ASLC6A2SLC6A4 | |
| SCHEMBL8121601 | 0.81 | RHEB (0.41) | RHEBGRIA1CACNG8P2RX7HTR1A | |
| SCHEMBL2332425 | 0.80 | RHEB (0.45) | RHEBHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8128707 | 0.79 | SLC6A2 (0.45) | RHEBHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8116807 | 0.78 | MPL (0.33) | RHEBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8653715 | 0.78 | GRIA1 (0.48) | RHEBGRIA1CACNG8P2RX7HTR1A | |
| SCHEMBL8122199 | 0.76 | RHEB (0.42) | RHEBHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8124037 | 0.76 | RHEB (0.42) | RHEBHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL621959 | 0.76 | EPHX2 (0.33) | — | |
| SCHEMBL146485 | 0.74 | SLC1A5 (0.34) | GRIA1CACNG8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |