Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4237630 | 0.81 | SLC18A3 (0.55) | SLC18A3SIGMAR1MEN1KMT2ACHRNB2 | |
| SCHEMBL15580371 | 0.81 | SLC18A3 (0.55) | SLC18A3SIGMAR1MEN1KMT2ACHRNB2 | |
| SCHEMBL8123312 | 0.75 | SLC18A3 (0.38) | SLC18A3SIGMAR1MEN1KMT2ACHRNB2 | |
| SCHEMBL8115602 | 0.75 | SLC18A3 (0.38) | SLC18A3SIGMAR1MEN1KMT2ACHRNB2 | |
| SCHEMBL8131218 | 0.75 | SLC18A3 (0.38) | SLC18A3SIGMAR1MEN1KMT2ACHRNB2 | |
| SCHEMBL8126333 | 0.73 | SLC18A3 (0.36) | SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL8131236 | 0.73 | SLC18A3 (0.36) | SLC18A3SIGMAR1MEN1KMT2ASLC6A2 | |
| SCHEMBL8130024 | 0.72 | SLC18A3 (0.35) | SLC18A3SIGMAR1MEN1KMT2APRCP | |
| SCHEMBL8130127 | 0.72 | HTR2C (0.35) | SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL8124539 | 0.72 | CHRNA7 (0.36) | SLC18A3SIGMAR1MEN1KMT2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | claimed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | claimed |
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |