Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.72 |
| ▸ | HTR1B | P28222 | 13/20 | 0.72 |
| ▸ | HTR1A | P08908 | 9/20 | 0.72 |
| ▸ | HTR2A | P28223 | 5/20 | 0.48 |
| ▸ | HTR2C | P28335 | 5/20 | 0.48 |
| ▸ | HTR2B | P41595 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604667 | 0.90 | HTR1D (0.74) | HTR1DHTR1BHTR1A | |
| SCHEMBL6604668 | 0.90 | HTR1D (0.74) | HTR1DHTR1BHTR1A | |
| SCHEMBL8138558 | 0.88 | HTR1D (0.65) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL6604652 | 0.86 | HTR1D (0.78) | HTR1DHTR1BHTR1A | |
| SCHEMBL6604656 | 0.86 | HTR1D (0.78) | HTR1DHTR1BHTR1A | |
| SCHEMBL8128398 | 0.85 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL8136370 | 0.85 | HTR1D (0.62) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL8131467 | 0.84 | HTR1D (0.66) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL8119106 | 0.81 | HTR1D (0.69) | HTR1DHTR1BHTR1AHTR2AHTR2C | |
| SCHEMBL6606137 | 0.80 | HTR1D (0.52) | HTR1DHTR1BHTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |