Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.65 |
| ▸ | CDK1 | P06493 | 10/20 | 0.65 |
| ▸ | SRC | P12931 | 8/20 | 0.65 |
| ▸ | ABL1 | P00519 | 14/20 | 0.64 |
| ▸ | PRKCA | P17252 | 9/20 | 0.64 |
| ▸ | ABL2 | P42684 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8115485 | 0.95 | EGFR (0.64) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6185990 | 0.93 | EGFR (0.67) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8130260 | 0.88 | EGFR (0.55) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8115748 | 0.87 | EGFR (0.77) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8114816 | 0.85 | EGFR (0.55) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8115535 | 0.85 | EGFR (0.74) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8117209 | 0.84 | EGFR (0.68) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8115045 | 0.84 | EGFR (0.78) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6190187 | 0.83 | EGFR (0.66) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8122574 | 0.83 | EGFR (0.70) | EGFRCDK1SRCABL1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819129-B1 | PYRAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2000-08-02 | — | — | EP | disclosed |
| US-5981533-A | INHIBIT THE TYROSINE KINASE ACTIVITY OF THE RECEPTOR FOR EPIDERMAL GROWTH FACTOR AND CAN BE USED IN THE CASE OF EPIDERMAL HYPERPROLIFERATION (PSORIASIS) AND AS ANTI-TUMOR AGENTS | NOVARTIS AG (CH) | 1999-11-09 | — | — | US | disclosed |
| EP-0819129-A1 | PYRAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031510-A1 | PYRAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1996-10-10 | — | — | WO | disclosed |