Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 5/20 | 0.49 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120242 | 0.91 | KCNH2 (0.62) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8133612 | 0.88 | MEN1 (0.49) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8136239 | 0.87 | MEN1 (0.52) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8132017 | 0.85 | MEN1 (0.52) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8129298 | 0.85 | KCNH2 (0.58) | KCNH2POLBTOP2ATOP2BALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL8131738 | 0.84 | KCNH2 (0.57) | KCNH2POLBTOP2ATOP2BALDH1A1 | |
| SCHEMBL9293428 | 0.83 | KCNH2 (0.53) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8131562 | 0.83 | POLB (0.63) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8110587 | 0.82 | POLB (0.61) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL9292952 | 0.82 | MEN1 (0.51) | MEN1KMT2AKCNH2POLBCACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342846-A | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents | SYNPHAR LABORATORIES, INC. (CA) | 1994-08-30 | — | — | US | claimed |
| WO-1993024481-A1 | 7-SUBSTITUTED-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID COMPOUNDS AND RELATED COMPOUNDS AS ANTIBACTERIAL AGENTS | SYNPHAR LABORATORIES, INC. (CA) | 1993-12-09 | — | — | WO | claimed |
| EP-0561850-B1 | 7-SUBSTITUTED-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS | NAEJA PHARMACEUTICAL INC (CA) | 2000-07-12 | — | — | EP | disclosed |
| US-5342846-A | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents | SYNPHAR LABORATORIES, INC. (CA) | 1994-08-30 | — | — | US | disclosed |