SCHEMBL8133205

SCHEMBL8133205

Cc1cn([C@H]2C[C@H](O)[C@@H](COS(=O)(=O)Cl)O2)c(=O)[nH]c1=O

nearest known ligand 0.66

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.62
TK1 P04183 5/20 0.59
TYMS P04818 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20109714 0.90 POLB (0.63) POLBTK1TYMS
SCHEMBL3345511 0.90 POLB (0.63) POLBTK1TYMS
SCHEMBL3514019 0.90 POLB (0.63) POLBTK1TYMS
SCHEMBL8146361 0.90 POLB (0.63) POLBTK1TYMS
SCHEMBL20115166 0.90 POLB (0.63) POLBTK1TYMS
SCHEMBL21163947 0.90 POLB (0.63) POLBTK1TYMS
SCHEMBL766555 0.87 TYMS (0.60) POLBTK1TYMS
SCHEMBL11876308 0.87 TYMS (0.60) POLBTK1TYMS
SCHEMBL11881949 0.87 TYMS (0.60) POLBTK1TYMS
SCHEMBL11876295 0.87 TYMS (0.60) POLBTK1TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6117988-A Nucleotides and oligonucleotides preparable therefrom ADVANCED RESEARCH & TECHNOLOGY INSTITUTE (US) 2000-09-12 US disclosed
US-5536823-A 3'-sulfonyl nucleoside compounds INDIANA UNIVERSITY FOUNDATION (US) 1996-07-16 US disclosed