Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.69 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.60 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.60 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.60 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.60 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.60 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | ARAF | P10398 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | BRAF | P15056 | 1/20 | 0.60 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773181 | 0.92 | RAF1 (0.79) | RAF1AURKAMAP1LC3BLRRK2MEN1 | |
| SCHEMBL5773177 | 0.92 | RAF1 (0.79) | RAF1AURKAMAP1LC3BLRRK2MEN1 | |
| SCHEMBL5774653 | 0.84 | RAF1 (0.73) | RAF1AURKAMAP1LC3BLRRK2MEN1 | |
| SCHEMBL5775441 | 0.82 | RAF1 (0.70) | RAF1AURKAMAP1LC3BLRRK2MEN1 | |
| SCHEMBL5775436 | 0.82 | RAF1 (0.70) | RAF1AURKAMAP1LC3BLRRK2MEN1 | |
| SCHEMBL5775570 | 0.82 | RAF1 (0.77) | RAF1AURKAMAP1LC3BLRRK2MEN1 | |
| SCHEMBL3757435 | 0.82 | RAF1 (0.77) | RAF1AURKAMAP1LC3BLRRK2MEN1 | |
| SCHEMBL1394836 | 0.81 | RAF1 (1.00) | RAF1AURKAMAP1LC3BLRRK2MEN1 | |
| SCHEMBL5776361 | 0.81 | RAF1 (1.00) | RAF1AURKAMAP1LC3BLRRK2MEN1 | |
| SCHEMBL5776365 | 0.81 | RAF1 (1.00) | RAF1AURKAMAP1LC3BLRRK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003721-A1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LIMITED (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999010325-A1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |