Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9420474 | 0.95 | SERPINE1 (0.49) | TSHRCYP3A4PRSS1PRSS2PRSS3 | |
| SCHEMBL9420514 | 0.95 | SERPINE1 (0.49) | TSHRCYP3A4PRSS1PRSS2PRSS3 | |
| SCHEMBL9420499 | 0.95 | SERPINE1 (0.49) | TSHRCYP3A4PRSS1PRSS2PRSS3 | |
| SCHEMBL9751347 | 0.93 | TDP1 (0.55) | TSHRCYP3A4PRSS1PRSS2PRSS3 | |
| SCHEMBL10524815 | 0.89 | SERPINE1 (0.44) | TSHRCYP3A4PRSS1PRSS2PRSS3 | |
| SCHEMBL813523 | 0.89 | PRSS1 (0.42) | TSHRCYP3A4PRSS1PRSS2PRSS3 | |
| SCHEMBL11847874 | 0.89 | PRSS1 (0.43) | TSHRCYP3A4PRSS1PRSS2PRSS3 | |
| SCHEMBL13611320 | 0.89 | TSHR (0.41) | TSHRCYP3A4PRSS1PRSS2PRSS3 | |
| SCHEMBL12152614 | 0.88 | PRSS1 (0.41) | TSHRCYP3A4PRSS1PRSS2PRSS3 | |
| SCHEMBL273609 | 0.87 | ESR1 (0.62) | TSHRCYP3A4ESR1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470954-B2 | Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant | ETHICON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-7968668-B2 | Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant | ETHICON INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7728097-B2 | Method of making a diisocyanate terminated macromer | ETHICON, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-20070276121-A1 | DIISOCYANATE TERMINATED MACROMER AND FORMULATION THEREOF FOR USE AS AN INTERNAL ADHESIVE OR SEALANT | ETHICON, INC. | 2007-11-29 | — | — | US | disclosed |
| US-20070167617-A1 | Method of making a diisocyanate terminated macromer | ETHICON, INC. | 2007-07-19 | — | — | US | disclosed |