Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.63 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 16/20 | 0.51 |
| ▸ | TOP2A | P11388 | 2/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135598 | 1.00 | CACNA1F (0.63) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL8135582 | 1.00 | CACNA1F (0.63) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL8132455 | 0.92 | CACNA1F (0.63) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL8132466 | 0.92 | CACNA1F (0.63) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL8132476 | 0.92 | CACNA1F (0.63) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9293277 | 0.91 | CACNA1F (0.68) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL8120142 | 0.86 | POLB (0.62) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9292834 | 0.86 | POLB (0.62) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL8135200 | 0.86 | POLB (0.62) | CACNA1FPOLBMAPK1CACNA1DKCNH2 | |
| SCHEMBL9293699 | 0.86 | CACNA1F (0.61) | CACNA1FPOLBMAPK1CACNA1DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0561850-B1 | 7-SUBSTITUTED-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS | NAEJA PHARMACEUTICAL INC (CA) | 2000-07-12 | — | — | EP | disclosed |
| US-5342846-A | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents | SYNPHAR LABORATORIES, INC. (CA) | 1994-08-30 | — | — | US | disclosed |
| WO-1993024481-A1 | 7-SUBSTITUTED-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID COMPOUNDS AND RELATED COMPOUNDS AS ANTIBACTERIAL AGENTS | SYNPHAR LABORATORIES, INC. (CA) | 1993-12-09 | — | — | WO | disclosed |