Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8119797 | 1.00 | COMT (0.44) | COMTTYRMEN1NR1I2LMNA | |
| SCHEMBL8130166 | 1.00 | COMT (0.44) | COMTTYRMEN1NR1I2LMNA | |
| SCHEMBL8137123 | 1.00 | COMT (0.44) | COMTTYRMEN1NR1I2LMNA | |
| SCHEMBL9291043 | 0.95 | COMT (0.45) | COMT | |
| SCHEMBL8130380 | 0.94 | PPARA (0.41) | COMTTYR | |
| SCHEMBL8135612 | 0.92 | PPARG (0.41) | MEN1LMNAKMT2A | |
| SCHEMBL8130001 | 0.90 | CYP11B1 (0.42) | COMTTYRMEN1NR1I2LMNA | |
| SCHEMBL8128366 | 0.90 | COMT (0.39) | COMTMEN1KMT2APTPN11 | |
| SCHEMBL8123164 | 0.90 | COMT (0.39) | COMTMEN1MAPTKMT2A | |
| SCHEMBL8126594 | 0.88 | PTPN11 (0.39) | TYRMEN1NR1I2LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0427765-B1 | ALKOXY-4(1H)-PYRIDONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USE AS DRUGS | GOEDECKE AG (DE) | 2000-01-05 | — | — | EP | disclosed |
| US-5322844-A | Cardiovascular disorders, antiinflammatory agents, antiallergens | GODECKE AKTIENGESELLSCHAFT (DE) | 1994-06-21 | — | — | US | disclosed |
| US-5185352-A | Treating or preventing cardiovascular disorders | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1993-02-09 | — | — | US | disclosed |
| EP-0427765-A1 | ALKOXY-4(1H)-PYRIDONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USE AS DRUGS | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-05-22 | — | — | EP | disclosed |
| WO-1990001477-A1 | ALKOXY-4(1H)-PYRIDONE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USE AS DRUGS | Gödecke Aktiengesellschaft (DE) | 1990-02-22 | — | — | WO | disclosed |
| EP-0354495-A1 | Alkoxy-4(1H)-pyridone derivatives, process for their preparation and their pharmaceutical use | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-02-14 | — | — | EP | disclosed |