SCHEMBL8138023

SCHEMBL8138023

COC(=O)Cc1ccc(O)cc1CC(=O)OC

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 5/20 0.59
ALDH1A1 P00352 4/20 0.55
GAA P10253 2/20 0.55
KDM4E B2RXH2 2/20 0.55
GLA P06280 2/20 0.55
HSP90AB1 P08238 1/20 0.53
GFER P55789 1/20 0.45
CA12 O43570 2/20 0.43
CA1 P00915 2/20 0.43
CA2 P00918 2/20 0.43
CA7 P43166 2/20 0.43
CA9 Q16790 2/20 0.43
CA14 Q9ULX7 2/20 0.43
HPGD P15428 2/20 0.43
TP53 P04637 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
ALOX15 P16050 1/20 0.43
ALOX12 P18054 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13760567 0.93 EGFR (0.56) EGFRALDH1A1GAAKDM4EGLA
SCHEMBL27474234 0.90 EGFR (0.54) EGFRALDH1A1GAAKDM4EGLA
SCHEMBL4751661 0.90 EGFR (0.54) EGFRALDH1A1GAAKDM4EGLA
SCHEMBL30605142 0.87 EGFR (0.75) EGFRALDH1A1GAAKDM4EGLA
SCHEMBL3545527 0.87 EGFR (0.75) EGFRALDH1A1GAAKDM4EGLA
SCHEMBL8764395 0.87 EGFR (0.57) EGFRALDH1A1GAAKDM4EGLA
SCHEMBL30619656 0.87 EGFR (0.57) EGFRALDH1A1GAAKDM4EGLA
SCHEMBL8878492 0.87 EGFR (0.51) EGFRALDH1A1GAAKDM4EGLA
SCHEMBL3922071 0.85 EGFR (0.52) EGFRALDH1A1GAAKDM4EGLA
SCHEMBL30582059 0.85 EGFR (0.52) EGFRALDH1A1GAAKDM4EGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6028090-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-02-22 US disclosed
US-5723480-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1998-03-03 US disclosed
US-5561148-A Adhesion receptor antagonists III MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) 1996-10-01 US disclosed