Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MDH2 | P40926 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CTSV | O60911 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8147522 | 0.95 | TNKS2 (0.60) | TNKS2PARP2ALDH1A1HPGDMDH2 | |
| SCHEMBL8139342 | 0.79 | KDM4E (0.49) | TNKS2PARP2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8140340 | 0.76 | PARP15 (0.51) | TNKS2PARP2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14867324 | 0.76 | SERPINE1 (0.55) | TNKS2PARP2HPGDCTSVCTSL | |
| SCHEMBL8133930 | 0.76 | GPR17 (0.50) | TNKS2ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL4078619 | 0.75 | TNKS2 (0.47) | TNKS2PARP2ALDH1A1HPGDMDH2 | |
| SCHEMBL6824331 | 0.75 | MAOB (0.56) | TNKS2PARP2ALDH1A1HPGDMDH2 | |
| SCHEMBL5504619 | 0.74 | KDM4E (0.69) | TNKS2PARP2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27389076 | 0.73 | KDM4E (0.56) | ALDH1A1HPGDMDH2SMN1; SMN2CTSV | |
| SCHEMBL2730788 | 0.73 | KDM4E (0.56) | ALDH1A1HPGDMDH2SMN1; SMN2CTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6093730-A | AN ENZYME INHIBITORS OF PROLYL-4-HYDROXYLASE FOR TREATING FIBROTIC DISORDERS AND INHIBITING COLLAGEN BIOSYNTHESIS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-07-25 | — | — | US | disclosed |