Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28352893 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1TP53KMT2AMAPT | |
| SCHEMBL22462478 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1TP53KMT2AMAPT | |
| SCHEMBL27920955 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1TP53KMT2AMAPT | |
| SCHEMBL8150014 | 0.81 | TP53 (0.39) | SMN1; SMN2ALDH1A1TP53KMT2AMAPT | |
| SCHEMBL14333359 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1TP53KMT2AMAPT | |
| SCHEMBL11820216 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1TP53KMT2AMAPT | |
| SCHEMBL27920936 | 0.72 | TP53 (0.39) | SMN1; SMN2ALDH1A1TP53KMT2AMAPT | |
| SCHEMBL8148844 | 0.71 | RECQL (0.46) | SMN1; SMN2ALDH1A1KMT2ATSHRRECQL | |
| SCHEMBL48851 | 0.69 | — | — | |
| Oxygen SCHEMBL27543875 | 0.68 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1TP53TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127548-A | PREPARING OPTIONALLY SUBSTITUED 3H-IMIDAZOLE-4-CARBALDEHYDE BY PROTECTING THE 3-AMINO GROUP, THEN FORMYLATING IN PRESENCE OF AN ORGANOMETALLIC COMPOUND AND ELECTROPHILE WITH FORMYL LEAVING GROUP, DEPROTECTING WITH ACID OR STRONG BASE | LONZA AG (CH) | 2000-10-03 | — | — | US | disclosed |
| EP-0965590-A1 | Process for the preparation of formylimidazoles | LONZA A.G. (CH) | 1999-12-22 | — | — | EP | disclosed |