Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.60 |
| ▸ | PDE1A | P54750 | 5/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PDE2A | O00408 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | PDE9A | O76083 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8141812 | 0.93 | PDE5A (0.56) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8140101 | 0.92 | PDE5A (0.56) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8144996 | 0.91 | PDE5A (0.60) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8141867 | 0.91 | PDE5A (0.57) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8141453 | 0.91 | PDE5A (0.59) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8141473 | 0.90 | PDE5A (0.56) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8141773 | 0.89 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8144966 | 0.88 | PDE5A (0.54) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8144987 | 0.88 | PDE5A (0.56) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL8132822 | 0.88 | PDE5A (0.56) | PDE5APDE1APDE1BPDE1CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866571-A | TREATMENT OF INFLAMMATIONS, THROMBOEMBOLIC DISEASES AND CARDIOVASCULAR DISEASES. | BAYER AKTIENGESELLSCHAFT (DE) | 1999-02-02 | — | — | US | claimed |
| US-6124303-A | MODULATING APOPTOSIS AND ELIMINATING AND INHIBITING GROWTH OF NEOPLASIAS SUCH AS PRECANCEROUS LESIONS | CELL PATHWAYS, INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-5866571-A | TREATMENT OF INFLAMMATIONS, THROMBOEMBOLIC DISEASES AND CARDIOVASCULAR DISEASES. | BAYER AKTIENGESELLSCHAFT (DE) | 1999-02-02 | — | — | US | disclosed |
| EP-0722943-A1 | 9-Substituted 2-(2-n-alkoxyphenyl)-purin-6-ones | BAYER AG (DE) | 1996-07-24 | — | — | EP | disclosed |