Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 2/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7135272 | 0.85 | PDGFRB (0.47) | AURKAAURKBDYRK1AMAPTKDM4E | |
| SCHEMBL26464174 | 0.85 | PDGFRB (0.47) | AURKAAURKBDYRK1AMAPTKDM4E | |
| SCHEMBL650259 | 0.84 | NPC1 (0.51) | ACACADYRK1AMAPTKDM4EALDH1A1 | |
| SCHEMBL7142078 | 0.84 | NPC1 (0.51) | ACACADYRK1AMAPTKDM4EALDH1A1 | |
| SCHEMBL8111883 | 0.82 | PDGFRB (0.47) | AURKAAURKBACP1ACACADYRK1A | |
| SCHEMBL7136950 | 0.81 | NR1H2 (0.43) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7139325 | 0.81 | IDO1 (0.42) | NR1H4MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL3136907 | 0.80 | NR1H2 (0.51) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3140919 | 0.80 | NR1H2 (0.51) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8119559 | 0.79 | AURKA (0.43) | AURKAAURKBACP1MAPTALDH1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996443-A1 | CERTAIN DIARYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF NPY SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 2000-05-03 | — | — | EP | disclosed |
| WO-1999001128-A1 | CERTAIN DIARYLIMIDAZOLE DERIVATIVES; A NEW CLASS OF NPY SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |