Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.59 |
| ▸ | SRC | P12931 | 12/20 | 0.59 |
| ▸ | ABL1 | P00519 | 10/20 | 0.59 |
| ▸ | ABL2 | P42684 | 10/20 | 0.59 |
| ▸ | KDR | P35968 | 6/20 | 0.58 |
| ▸ | LCK | P06239 | 5/20 | 0.58 |
| ▸ | RET | P07949 | 3/20 | 0.58 |
| ▸ | KIF5B | P33176 | 3/20 | 0.58 |
| ▸ | FLT3 | P36888 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.58 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | NPM1 | P06748 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | ROS1 | P08922 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | KIT | P10721 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8138258 | 0.88 | SRC (0.63) | EGFRSRCABL1ABL2KDR | |
| SCHEMBL12934115 | 0.80 | SRC (0.75) | EGFRSRCABL1ABL2KDR | |
| SCHEMBL7005965 | 0.79 | EGFR (0.57) | EGFRSRCABL1ABL2KDR | |
| SCHEMBL13020005 | 0.78 | SRC (0.78) | EGFRSRCABL1ABL2KDR | |
| SCHEMBL12934112 | 0.77 | SRC (0.56) | EGFRSRCABL1ABL2KDR | |
| SCHEMBL2075497 | 0.76 | SRC (0.68) | EGFRSRCABL1ABL2KDR | |
| SCHEMBL7006750 | 0.74 | SRC (0.61) | EGFRSRCABL1ABL2KDR | |
| SCHEMBL18044541 | 0.73 | SRC (0.81) | EGFRSRCABL1ABL2KDR | |
| SCHEMBL12934136 | 0.73 | TEK (0.62) | EGFRSRCABL1ABL2KDR | |
| SCHEMBL2071933 | 0.72 | SRC (0.76) | EGFRSRCABL1ABL2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-A1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998041525-A1 | PYRROLO[2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-24 | — | — | WO | disclosed |