Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16255742 | 0.84 | TDP1 (0.53) | NOTUMEGFRMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL28669018 | 0.84 | SRD5A2 (0.57) | POLBTSHRNOTUMEGFRAKR1C3 | |
| SCHEMBL497989 | 0.84 | CA12 (0.53) | GAANOTUMEGFRTP53AKR1C3 | |
| SCHEMBL21300493 | 0.82 | GLA (0.58) | GAAGLAPOLBTSHRAKR1C3 | |
| SCHEMBL8141484 | 0.82 | GLA (0.58) | GAAGLAPOLBTSHRAKR1C3 | |
| SCHEMBL12141744 | 0.82 | NOTUM (0.49) | POLBNOTUMEGFRAKR1C3AKR1C2 | |
| SCHEMBL14791904 | 0.82 | EGFR (0.60) | GAANOTUMEGFRAKR1C3AKR1C2 | |
| Methoxymethane SCHEMBL28910833 | 0.82 | GLA (0.66) | GAAGLAPOLBTSHRAKR1C3 | |
| SCHEMBL15920972 | 0.81 | KDM4E (0.55) | NOTUMEGFRMAPTSMN1; SMN2AKR1C3 | |
| Methyl Alcohol SCHEMBL28910832 | 0.80 | GLA (0.68) | GAAGLAPOLBTSHRAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100272-A | Tetracyclic spiro compounds as 5HT1B receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-08-08 | — | — | US | disclosed |
| EP-0888358-A1 | PIPERIDINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034901-A1 | PIPERIDINE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-09-25 | — | — | WO | disclosed |