Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 2/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065122 | 0.76 | GPBAR1 (0.44) | OXTRAVPR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8128605 | 0.74 | HTR2C (0.48) | OXTRAVPR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4062330 | 0.74 | HTR2C (0.48) | OXTRAVPR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8144329 | 0.74 | SLC6A2 (0.38) | OXTRAVPR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4063945 | 0.73 | GPBAR1 (0.48) | OXTRAVPR1ALIPESMN1; SMN2HTT | |
| SCHEMBL7547286 | 0.73 | GPBAR1 (0.45) | OXTRAVPR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4069077 | 0.66 | CYP1A2 (0.41) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL4066243 | 0.66 | CYP1A2 (0.40) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL4061973 | 0.65 | KDM4E (0.60) | SLC6A2SLC6A4SLC6A3CYP1A2CYP3A4 | |
| SCHEMBL4058614 | 0.64 | GRM8 (0.53) | LMNAPOLBHTR2CGRM8GRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |