Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | HK2 | P52789 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3273499 | 0.81 | BACE1 (0.75) | BACE1PTPN1PDE4B | |
| SCHEMBL8144121 | 0.77 | BACE1 (0.47) | BACE1PTPN1PTPN6AKR1C3AKR1C2 | |
| SCHEMBL93342 | 0.75 | KMT2A (0.48) | NSD2 | |
| Water SCHEMBL27382344 | 0.73 | KMT2A (0.47) | NSD2 | |
| SCHEMBL1706197 | 0.73 | KMT2A (0.47) | NSD2 | |
| SCHEMBL10711952 | 0.73 | KMT2A (0.47) | NSD2 | |
| SCHEMBL27509115 | 0.72 | FFAR4 (0.44) | BACE1AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL9472211 | 0.72 | PTPN1 (0.53) | BACE1PTPN1PTPN6AKR1C3AKR1C2 | |
| SCHEMBL5989278 | 0.72 | BACE1 (0.73) | BACE1HDAC8HDAC4HDAC2PDE4B | |
| SCHEMBL9469340 | 0.70 | PTPN1 (0.63) | BACE1PTPN1PTPN6AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017918-A | Phenyl glycine compounds and methods of treating atherosclerosis and restenosis | WARNER-LAMBERT COMPANY (US) | 2000-01-25 | — | — | US | disclosed |