Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | EDNRA | P25101 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | PPARG | P37231 | 13/20 | 0.54 |
| ▸ | RXRA | P19793 | 6/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8147451 | 1.00 | CYP1A2 (0.69) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL7638115 | 1.00 | CYP1A2 (0.69) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL8148367 | 0.91 | CYP1A2 (0.57) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL8148370 | 0.91 | CYP1A2 (0.57) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL2267419 | 0.90 | CYP1A2 (0.79) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL7633646 | 0.90 | CYP1A2 (0.79) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL8150873 | 0.90 | CYP1A2 (0.79) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL9711041 | 0.90 | CYP1A2 (0.56) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL9711061 | 0.89 | CYP1A2 (0.53) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL8148125 | 0.87 | CYP1A2 (0.51) | CYP1A2MAPTMAPK1TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028116-A | Substituted condensation products of 1H-indenyl-hydroxyalkanes with aldehydes for neoplasia | CELL PATHWAYS, INC. (US) | 2000-02-22 | — | — | US | disclosed |
| US-5776962-A | Lactone compounds for treating patient with precancerous lesions | CELL PATHWAYS, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5696159-A | Lactone compounds for treating patients with precancerous lesions | CELL PATHWAYS, INC. (US) | 1997-12-09 | — | — | US | disclosed |