Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 6/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 6/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 6/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8153428 | 0.90 | TP53 (0.36) | KMT2AMEN1SCN1ASCN2ASCN3A | |
| SCHEMBL8149803 | 0.89 | TP53 (0.37) | KMT2AMEN1 | |
| SCHEMBL8146061 | 0.89 | TP53 (0.37) | KMT2AMEN1 | |
| SCHEMBL8141664 | 0.88 | MEN1 (0.33) | KMT2AMEN1SCN1ASCN2ASCN3A | |
| SCHEMBL8147981 | 0.88 | MEN1 (0.33) | KMT2AMEN1SCN1ASCN2ASCN3A | |
| SCHEMBL8147004 | 0.87 | BCHE (0.42) | KMT2AMEN1CHRM1 | |
| SCHEMBL8142163 | 0.87 | CHRM3 (0.35) | KMT2AMEN1SCN1ASCN2ASCN3A | |
| SCHEMBL8141070 | 0.84 | CHRNA7 (0.32) | — | |
| SCHEMBL8141746 | 0.81 | MEN1 (0.32) | KMT2AMEN1 | |
| SCHEMBL8141718 | 0.81 | MEN1 (0.32) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741729-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995021170-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-10 | — | — | WO | claimed |
| US-6013807-A | Antitumor tetracyclic compounds | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2000-01-11 | — | — | US | disclosed |
| US-5852204-A | Pyrrolo 3,2-b-!-carbazoles and 1H 1!benzothieno 2,3-f! indoles having anti-tumor activity | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1998-12-22 | — | — | US | disclosed |
| EP-0741729-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995021170-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-10 | — | — | WO | disclosed |