Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.83 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626709 | 1.00 | HDAC6 (0.83) | HDAC6ADORA2AADORA3ADORA1PDE2A | |
| Maribavir SCHEMBL13640277 | 0.91 | HDAC6 (1.00) | HDAC6ADORA2AADORA3ADORA1KDM4E | |
| Maribavir SCHEMBL13641210 | 0.91 | HDAC6 (1.00) | HDAC6ADORA2AADORA3ADORA1KDM4E | |
| Maribavir SCHEMBL7638886 | 0.91 | HDAC6 (1.00) | HDAC6ADORA2AADORA3ADORA1KDM4E | |
| Maribavir SCHEMBL18459376 | 0.91 | HDAC6 (1.00) | HDAC6ADORA2AADORA3ADORA1KDM4E | |
| Maribavir SCHEMBL1028527 | 0.91 | HDAC6 (1.00) | HDAC6ADORA2AADORA3ADORA1KDM4E | |
| Maribavir SCHEMBL7634766 | 0.91 | HDAC6 (1.00) | HDAC6ADORA2AADORA3ADORA1KDM4E | |
| Maribavir SCHEMBL7634149 | 0.91 | HDAC6 (1.00) | HDAC6ADORA2AADORA3ADORA1KDM4E | |
| Maribavir SCHEMBL13082009 | 0.91 | HDAC6 (1.00) | HDAC6ADORA2AADORA3ADORA1KDM4E | |
| Maribavir SCHEMBL18459197 | 0.91 | HDAC6 (1.00) | HDAC6ADORA2AADORA3ADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019425-A1 | MODIFIED BENZIMIDAZOLE NUCLEOSIDES AS ANTIVIRAL AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2000-07-19 | — | — | EP | disclosed |
| US-5840743-A | TREATING HERPES VIRUS, CYTOMEGALO VIRUS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1998-11-24 | — | — | US | disclosed |
| WO-1997027204-A1 | MODIFIED BENZIMIDAZOLE NUCLEOSIDES AS ANTIVIRAL AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1997-07-31 | — | — | WO | disclosed |