Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.71 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8148755 | 1.00 | MAPT (0.78) | MAPTKDM4ELMNATNFRSF1AABCG2 | |
| SCHEMBL9113047 | 0.93 | KDM4E (0.82) | MAPTKDM4ELMNATNFRSF1AABCG2 | |
| SCHEMBL9113057 | 0.93 | KDM4E (0.82) | MAPTKDM4ELMNATNFRSF1AABCG2 | |
| SCHEMBL25200497 | 0.87 | MAPT (0.69) | MAPTKDM4ELMNATNFRSF1AABCG2 | |
| SCHEMBL25209892 | 0.87 | MAPT (0.69) | MAPTKDM4ELMNATNFRSF1AABCG2 | |
| SCHEMBL29576289 | 0.87 | MAPT (0.76) | MAPTKDM4ELMNATNFRSF1AABCG2 | |
| SCHEMBL25193831 | 0.87 | MAPT (0.69) | MAPTKDM4ELMNATNFRSF1AABCG2 | |
| SCHEMBL25218301 | 0.87 | MAPT (0.69) | MAPTKDM4ELMNATNFRSF1AABCG2 | |
| SCHEMBL30383815 | 0.87 | MAPT (0.69) | MAPTKDM4ELMNATNFRSF1AABCG2 | |
| SCHEMBL23788887 | 0.86 | ABCG2 (0.84) | ABCG2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0996432-A2 | BIOLOGICALLY ACTIVE 1,3-BIS-AROMATIC-PROP-2-EN-1-ONES, 1,3-BIS-AROMATIC-PROPAN-1-ONES, AND 1,3-BIS-AROMATIC-PROP-2-YN-1-ONES | STATENS SERUMINSTITUT (DK) | 2000-05-03 | — | — | EP | disclosed |
| WO-1999000114-A2 | BIOLOGICALLY ACTIVE 1,3-BIS-AROMATIC-PROP-2-EN-1-ONES, 1,3-BIS-AROMATIC-PROPAN-1-ONES, AND 1,3-BIS-AROMATIC-PROP-2-YN-1-ONES | STATENS SERUM INSTITUT (DK) | 1999-01-07 | — | — | WO | disclosed |