Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 20/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 20/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 20/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL815405 | 0.89 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL815414 | 0.89 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL815412 | 0.89 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL815256 | 0.89 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL815019 | 0.82 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL815886 | 0.82 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL813403 | 0.82 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL814886 | 0.82 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL814887 | 0.82 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL815197 | 0.82 | SLC6A2 (0.76) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053603-B2 | Tetralone-based monoamine reuptake inhibitors | SUNOVION PHARMACEUTICALS INC. (US) | 2011-11-08 | — | — | US | disclosed |