Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | TEK | Q02763 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 2/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 3/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.52 |
| ▸ | VCP | P55072 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.49 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8150558 | 0.91 | EGFR (0.76) | EGFRERBB2KDRTEKRIPK2 | |
| SCHEMBL8143063 | 0.88 | EGFR (0.68) | EGFRERBB2KDRCSF1RFYN | |
| SCHEMBL7237980 | 0.86 | EGFR (0.84) | EGFRERBB2KDRTEKCSF1R | |
| SCHEMBL4187418 | 0.82 | EGFR (0.69) | EGFRERBB2EPHB2FYNSRC | |
| SCHEMBL7241072 | 0.80 | KDR (0.61) | EGFRERBB2KDRTEKCSF1R | |
| SCHEMBL7241075 | 0.80 | KDR (0.61) | EGFRERBB2KDRTEKCSF1R | |
| SCHEMBL7239977 | 0.80 | EGFR (1.00) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL7238977 | 0.79 | EGFR (0.73) | EGFRERBB2KDRTEKRIPK2 | |
| SCHEMBL8154615 | 0.79 | EGFR (0.77) | EGFRERBB2FYNSRCERBB4 | |
| SCHEMBL8810802 | 0.79 | EGFR (0.77) | EGFRERBB2KDRTEKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127374-A | AN ENZYME INHIBITOR FOR TREATING CANCER, RESTENOSIS, ATHEROSCLEROSIS, ENDOMETRIOSIS AND PSORIASIS | WARNER-LAMBERT COMPANY (US) | 2000-10-03 | — | — | US | claimed |
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |