Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | FNTA | P49354 | 8/20 | 0.36 |
| ▸ | FNTB | P49356 | 8/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 6/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149160 | 1.00 | MEN1 (0.38) | MEN1FNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL8147915 | 0.84 | FNTA (0.36) | FNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL8147914 | 0.84 | FNTA (0.36) | FNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL2917462 | 0.83 | PTGDR2 (0.35) | FNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL8156285 | 0.80 | TSHR (0.37) | MEN1FNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL2913313 | 0.78 | SIRT2 (0.35) | MEN1FNTAFNTBPGGT1B | |
| SCHEMBL2909984 | 0.78 | SIRT2 (0.34) | — | |
| SCHEMBL2787655 | 0.76 | CYP19A1 (0.36) | MEN1CYP19A1 | |
| SCHEMBL2787652 | 0.76 | CYP19A1 (0.36) | MEN1CYP19A1 | |
| SCHEMBL2914446 | 0.72 | HTT (0.36) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6077853-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-06-20 | — | — | US | disclosed |
| EP-0951285-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998029119-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | disclosed |