Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 5/20 | 0.39 |
| ▸ | FNTB | P49356 | 5/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149630 | 0.94 | CYP19A1 (0.40) | CYP19A1FNTAFNTBPGGT1B | |
| SCHEMBL8151360 | 0.90 | CYP19A1 (0.42) | CYP19A1FNTAFNTBPGGT1B | |
| SCHEMBL8157261 | 0.89 | FNTA (0.39) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8155427 | 0.86 | FNTA (0.41) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8151571 | 0.83 | CYP11B1 (0.42) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8150556 | 0.83 | FNTA (0.41) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8009897 | 0.83 | CYP11B1 (0.49) | CYP19A1FNTAFNTBPGGT1BCYP11B1 | |
| SCHEMBL8157269 | 0.82 | CYP11B1 (0.39) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL8154241 | 0.82 | FNTA (0.48) | FNTAFNTBPGGT1B | |
| SCHEMBL8151756 | 0.82 | CYP11B1 (0.50) | CYP19A1FNTAFNTBPGGT1BCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951285-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-10-27 | — | — | EP | claimed |
| WO-1998029119-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | claimed |
| US-6077853-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 2000-06-20 | — | — | US | disclosed |
| EP-0951285-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998029119-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1998-07-09 | — | — | WO | disclosed |