Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047559 | 0.81 | MEN1 (0.33) | NPSR1HTR2CLMNAMAPTHTT | |
| SCHEMBL9046855 | 0.80 | BRD4 (0.33) | — | |
| SCHEMBL9296006 | 0.79 | PTGS1 (0.49) | NPSR1CA12CA2CA9ALOX5 | |
| SCHEMBL9147516 | 0.79 | P2RY6 (0.38) | P2RY6 | |
| SCHEMBL7269294 | 0.75 | CA12 (0.39) | CA12CA9P2RY6MALT1 | |
| SCHEMBL9147344 | 0.75 | PTGS1 (0.40) | CA12CA9 | |
| SCHEMBL8156069 | 0.70 | NR1H2 (0.40) | NPSR1LMNAMAPT | |
| SCHEMBL482227 | 0.69 | NPSR1 (0.49) | NPSR1AHRCA12CA2CA9 | |
| SCHEMBL8680866 | 0.69 | — | — | |
| SCHEMBL8141635 | 0.68 | PTGIR (0.36) | HTR2CALOX5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071938-A | FOR TREATMENT OF SMOOTH MUSCLE DISORDERS | PFIZER INC. (US) | 2000-06-06 | — | — | US | disclosed |
| US-5912244-A | MUSCLE DISORDERS, BREATHING DISORDERS AND URINARY INCONTINENCE | PFIZER INC. (US) | 1999-06-15 | — | — | US | disclosed |
| US-5677324-A | MUSCLE RELAXANTS | PFIZER INC. (US) | 1997-10-14 | — | — | US | disclosed |
| EP-0712398-B1 | BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER LTD (GB) | 1997-05-07 | — | — | EP | disclosed |
| EP-0690855-B1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LTD (GB) | 1996-12-18 | — | — | EP | disclosed |
| EP-0712398-A1 | BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER LTD (GB) | 1996-05-22 | — | — | EP | disclosed |
| US-5447943-A | Smooth muscle relaxants or bronchodilators | SYNTEX (U.S.A.) INC. (US) | 1995-09-05 | — | — | US | disclosed |
| WO-1995004730-A1 | BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER LIMITED (GB) | 1995-02-16 | — | — | WO | disclosed |
| WO-1994020491-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |
| US-5250547-A | Potassium channel activators; 5-lipoxygenase inhibitors; muscle relaxants; bronchodilators | SYNTEX (U.S.A.) INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0529654-A1 | Benzopyran derivatives as potassium channel activators and 5-lipoxygenase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1993-03-03 | — | — | EP | disclosed |