Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 12/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8152311 | 0.81 | PPARA (0.47) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL3686992 | 0.75 | PPARA (0.56) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL14398599 | 0.75 | PPARA (0.61) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL3686994 | 0.73 | PPARA (0.56) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL10590453 | 0.70 | PPARA (0.66) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL10590114 | 0.70 | PPARA (0.66) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL23040068 | 0.69 | PPARA (0.68) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL1549122 | 0.69 | PPARA (0.68) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL3823703 | 0.69 | PPARA (0.71) | PPARACYP3A4ABCB11CYP1A2TSHR | |
| SCHEMBL11548436 | 0.68 | PPARA (0.76) | PPARACYP3A4ABCB11CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028109-A | Use of agonists of the peroxisome proliferator activated receptor alpha for treating obesity | GLAXO WELLCOME INC. (US) | 2000-02-22 | — | — | US | disclosed |
| WO-1997036579-A1 | USE OF AGONISTS OF THE PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA FOR TREATING OBESITY | GLAXO GROUP LIMITED (GB) | 1997-10-09 | — | — | WO | disclosed |