Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.56 |
| ▸ | PDE4A | P27815 | 7/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31535540 | 0.86 | KMT2A (0.56) | PARP10PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2562290 | 0.83 | KMT2A (0.59) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL8154363 | 0.82 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL31535406 | 0.82 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL13451038 | 0.81 | PARP10 (0.61) | PARP10PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL29710989 | 0.81 | PARP10 (0.49) | PARP10PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2563365 | 0.81 | KMT2A (0.47) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL2543514 | 0.80 | KMT2A (0.51) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL20021947 | 0.79 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL4728938 | 0.79 | PDE4B (0.80) | PDE4BPDE4DPDE4APDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071927-A | Spiro-piperidine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2000-06-06 | — | — | US | disclosed |