Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naphthoquinone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.70 |
| ▸ | CDC25B | P30305 | 6/20 | 0.70 |
| ▸ | MAOA | P21397 | 3/20 | 0.70 |
| ▸ | MAOB | P27338 | 2/20 | 0.70 |
| ▸ | SNCA | P37840 | 2/20 | 0.70 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.70 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.70 |
| ▸ | AKT1 | P31749 | 1/20 | 0.70 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.70 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.70 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | THRB | P10828 | 4/20 | 0.48 |
| ▸ | RECQL | P46063 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthoquinone SCHEMBL5157257 | 0.95 | IDO1 (0.70) | IDO1CDC25BMAOAMAOBSNCA | |
| Naphthoquinone SCHEMBL29148131 | 0.84 | CDC25B (0.61) | IDO1CDC25BMAOAMAOBSNCA | |
| Naphthoquinone SCHEMBL42139 | 0.84 | IDO1 (1.00) | IDO1CDC25BMAOAMAOBSNCA | |
| Naphthoquinone SCHEMBL8861335 | 0.84 | IDO1 (1.00) | IDO1CDC25BMAOAMAOBSNCA | |
| Naphthoquinone SCHEMBL11359780 | 0.84 | IDO1 (1.00) | IDO1CDC25BMAOAMAOBSNCA | |
| Naphthoquinone SCHEMBL29354680 | 0.84 | IDO1 (1.00) | IDO1CDC25BMAOAMAOBSNCA | |
| Naphthoquinone SCHEMBL9189533 | 0.82 | IDO1 (0.74) | IDO1CDC25BMAOAMAOBSNCA | |
| Naphthoquinone SCHEMBL27601003 | 0.82 | IDO1 (0.74) | IDO1CDC25BMAOAMAOBSNCA | |
| Naphthoquinone SCHEMBL28746711 | 0.82 | IDO1 (0.74) | IDO1CDC25BMAOAMAOBSNCA | |
| Anthraquinone SCHEMBL5162013 | 0.81 | IDO1 (0.82) | IDO1CDC25BMAOAMAOBSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1018870-A1 | SURFACTANTS FOR USE IN AGRICULTURAL FORMULATIONS | HENKEL CORPORATION (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999003343-A1 | SURFACTANTS FOR USE IN AGRICULTURAL FORMULATIONS | HENKEL CORPORATION (US) | 1999-01-28 | — | — | WO | disclosed |
| WO-1995028410-A1 | BIOLOGICALLY ACTIVE COMPOSITION | HENKEL CORPORATION (US) | 1995-10-26 | — | — | WO | disclosed |