SCHEMBL8157307

SCHEMBL8157307

O=C1CN(Cc2c[nH]cn2)CCN1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.40
ATM Q13315 1/20 0.40
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.36
KDM5C P41229 1/20 0.36
KDM4C Q9H3R0 1/20 0.36
PARP1 P09874 1/20 0.36
SCN9A Q15858 3/20 0.36
SLC2A1 P11166 2/20 0.35
PDCD1 Q15116 1/20 0.35
CD274 Q9NZQ7 1/20 0.35
CYP11B2 P19099 1/20 0.35
GRM5 P41594 1/20 0.35
SLC2A2 P11168 1/20 0.35
PIK3R1 P27986 1/20 0.35
PIK3CA P42336 1/20 0.35
THRB P10828 2/20 0.34
PDE10A Q9Y233 1/20 0.34
CXCR4 P61073 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19046435 0.80 CXCR4 (0.45) KMT2AALDH1A1KDM5CKDM4CCXCR4
SCHEMBL22175530 0.76 KMT2A (0.54) KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL3316994 0.74 KMT2A (0.41) KMT2AATMKDM4EALDH1A1SMN1; SMN2
SCHEMBL15206491 0.74 KDM5C (0.49) KMT2AATMKDM4EALDH1A1SMN1; SMN2
SCHEMBL22548971 0.73 HRH3 (0.41) KDM4ECXCR4
SCHEMBL10516778 0.73 HRH3 (0.43)
SCHEMBL15206345 0.72 KMT2A (0.40) KMT2AATMKDM4EALDH1A1SMN1; SMN2
SCHEMBL17409802 0.72 PDCD1 (0.42) KMT2AATMKDM4EALDH1A1SMN1; SMN2
SCHEMBL17403599 0.72 SCN9A (0.41) KMT2AATMKDM4EALDH1A1SMN1; SMN2
SCHEMBL20456859 0.72 EED (0.41) KMT2AATMKDM4EALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2000508335-A 2000-07-04 JP claimed
EP-0934270-A1 A METHOD OF TREATING CANCER Merck & Co., Inc. (US) 1999-08-11 EP claimed
WO-1997045412-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 1997-12-04 WO claimed
WO-2025133915-A1 COMPOUNDS WHICH BIND TO PNPLA3I148M AND THEIR USE TO TREAT LIVER DISEASES NOVARTIS AG (CH) 2025-06-26 WO disclosed
EP-0952842-A2 A METHOD OF TREATING CANCER Merck & Co., Inc. (US) 1999-11-03 EP disclosed
EP-0934270-A1 A METHOD OF TREATING CANCER Merck & Co., Inc. (US) 1999-08-11 EP disclosed
WO-1997045412-A1 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 1997-12-04 WO disclosed
WO-1997038664-A2 A METHOD OF TREATING CANCER MERCK & CO., INC. (US) 1997-10-23 WO disclosed