Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8158311 | 0.91 | SRD5A2 (0.80) | SRD5A2L3MBTL1TSHRMAPTMAPK1 | |
| SCHEMBL9352477 | 0.85 | SRD5A2 (0.50) | SRD5A2MAPTHTTPOLBADRA1D | |
| SCHEMBL9319481 | 0.84 | SRD5A2 (0.80) | SRD5A2L3MBTL1TSHRMAPTMAPK1 | |
| SCHEMBL8158368 | 0.82 | SRD5A2 (0.65) | SRD5A2L3MBTL1TSHRMAPTTDP1 | |
| SCHEMBL8162801 | 0.82 | SRD5A2 (0.66) | SRD5A2L3MBTL1TSHRMAPTMAPK1 | |
| SCHEMBL8156605 | 0.82 | SRD5A2 (0.72) | SRD5A2L3MBTL1MAPTTDP1POLB | |
| SCHEMBL10422174 | 0.81 | SRD5A2 (0.66) | SRD5A2L3MBTL1TSHRMAPTTDP1 | |
| SCHEMBL8151661 | 0.81 | SRD5A2 (0.63) | SRD5A2L3MBTL1TSHRTDP1POLB | |
| SCHEMBL8159789 | 0.80 | SRD5A2 (1.00) | SRD5A2L3MBTL1TSHRMAPTMAPK1 | |
| SCHEMBL8162470 | 0.80 | SRD5A2 (0.67) | SRD5A2L3MBTL1TSHRMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046183-A | SYNERGISTIC MIXTURE OF FINASTERIDE AND DOXAZOSIN | MERCK & CO., INC. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5994362-A | ADMINISTERING FINASTERIDE AND CASODEX | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1992018132-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA COMTAINING A 5 ALPHA-REDUCTASE INHIBITOR | MERCK & CO., INC. (US) | 1992-10-29 | — | — | WO | disclosed |
| WO-1992016233-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| EP-0291245-B1 | BENZOYLAMINOPHENOXYBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-07-22 | — | — | EP | disclosed |
| US-4980372-A | INHIBITORS OF 5-ALPHA-REDUCTASE; TREATING AND PREVENTING ALOPECIA, ACNES OR PROSTATIC HYPERTROPHY | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-12-25 | — | — | US | disclosed |
| EP-0291245-A2 | Benzoylaminophenoxybutanoic acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-11-17 | — | — | EP | disclosed |