Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.77 |
| ▸ | CTSD | P07339 | 2/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | REN | P00797 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13953513 | 1.00 | BACE1 (0.77) | BACE1CTSDBACE2APPREN | |
| SCHEMBL8150922 | 1.00 | BACE1 (0.77) | BACE1CTSDBACE2APPREN | |
| SCHEMBL13953594 | 0.92 | BACE1 (0.64) | BACE1CTSDBACE2APPREN | |
| SCHEMBL13953232 | 0.91 | BACE1 (0.71) | BACE1CTSDBACE2APPREN | |
| SCHEMBL8152927 | 0.90 | BACE1 (0.62) | BACE1CTSDBACE2APPREN | |
| SCHEMBL13953336 | 0.90 | BACE1 (0.72) | BACE1CTSDBACE2APPREN | |
| SCHEMBL13953233 | 0.88 | BACE1 (0.63) | BACE1CTSDBACE2APPREN | |
| SCHEMBL13953234 | 0.88 | BACE1 (0.63) | BACE1CTSDBACE2APPREN | |
| SCHEMBL4309479 | 0.88 | BACE1 (0.64) | BACE1CTSDBACE2APPREN | |
| SCHEMBL13953593 | 0.88 | BACE1 (0.62) | BACE1CTSDBACE2APPREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115552-A1 | AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5- PHENYLIMIDAZOLONE COMPOUNDS AS ß-SECRETASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | WO | disclosed |