⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10361225 | 1.00 | — | — | |
| SCHEMBL8160496 | 1.00 | — | — | |
| SCHEMBL10361224 | 1.00 | — | — | |
| SCHEMBL10859016 | 0.91 | HMGCR (0.41) | — | |
| SCHEMBL5499193 | 0.88 | HMGCR (0.39) | — | |
| SCHEMBL5499192 | 0.88 | HMGCR (0.39) | — | |
| SCHEMBL9663551 | 0.87 | HMGCR (0.40) | — | |
| SCHEMBL10798111 | 0.87 | HMGCR (0.40) | — | |
| SCHEMBL10361221 | 0.86 | — | — | |
| SCHEMBL10361089 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567289-A | ANTICHOLESTEROL ANTILIPEMIC | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | claimed |
| EP-1054860-A1 | PROCESS FOR THE SYNTHESIS OF 1,3-DIOLS | Warner-Lambert Export Limited (IE) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999032434-A1 | PROCESS FOR THE SYNTHESIS OF 1,3-DIOLS | WARNER-LAMBERT EXPORT LIMITED (IE) | 1999-07-01 | — | — | WO | disclosed |
| US-5258544-A | Synthesis of aldehydes useful in the preparations of HMG-CoA reductase inhibitors | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-11-02 | — | — | US | disclosed |
| US-5248830-A | Enantioselective preparation of acetylenic or olefinic substituted cycloalkenyl dihydroxybutyrates and 4-hydroxy-tetrahydro-pyran-2-ones | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1993-09-28 | — | — | US | disclosed |
| EP-0259087-B1 | PRODRUGS OF ANTIHYPERCHOLESTEROLEMIC COMPOUNDS | MERCK & CO. INC. (US) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992014692-A1 | ENANTIOSELECTIVE PREPARATION OF ACETYLENIC OR OLEFINIC SUBSTITUTED CYCLOALKENYL DIHYDROXYBUTYRATES AND 4-HYDROXY-TETRAHYDROPYRAN-2-ONES | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-09-03 | — | — | WO | disclosed |
| US-5132312-A | 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors as anticholesterol agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-07-21 | — | — | US | disclosed |
| US-5114964-A | Aryl-substituted benzocycloalkyl-derived anti-atherosclerotic agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0262852-B1 | PRODRUGS OF ANTIHYPERCHOLOESTEROLEMIC COMPOUNDS | MERCK & CO. INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| US-4904691-A | Novel HMG-CoA reductase inhibitors | RORER PHARMACEUTICAL CORPORATION (US) | 1990-02-27 | — | — | US | disclosed |
| US-4900754-A | ANTICHOLESTEROL AGENTS | RORER PHARMACEUTICAL CORP. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4892884-A | ANTICHOLESTEROL, ANTILIPEMIC | RORER PHARMACEUTICAL CORPORATION (US) | 1990-01-09 | — | — | US | disclosed |
| US-4863957-A | ANTICHOLESTEROL AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| US-4837205-A | 1,3-DIOXANE DERIVATIVES | MERCK & CO., INC. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0262852-A2 | Prodrugs of antihypercholoesterolemic compounds | MERCK & CO. INC. (US) | 1988-04-06 | — | — | EP | disclosed |
| US-4736064-A | ANTICHOLESTEROL, ANTILIPEMIC AGENTS | MERCK & CO., INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0259087-A2 | Prodrugs of antihypercholesterolemic compounds | MERCK & CO. INC. (US) | 1988-03-09 | — | — | EP | disclosed |
| US-4567289-A | ANTICHOLESTEROL ANTILIPEMIC | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4567289-A | ANTICHOLESTEROL ANTILIPEMIC | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |