Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8165202 | 1.00 | HIF1A (0.46) | HIF1AOPRL1MAPK14FFAR1FFAR4 | |
| SCHEMBL8158961 | 0.89 | HIF1A (0.47) | HIF1AFFAR1PTPN1 | |
| SCHEMBL8158964 | 0.89 | HIF1A (0.47) | HIF1AFFAR1PTPN1 | |
| SCHEMBL5080367 | 0.89 | HIF1A (0.43) | HIF1AOPRL1PPARDPPARAPPARG | |
| SCHEMBL15315953 | 0.85 | HIF1A (0.56) | HIF1A | |
| SCHEMBL9894742 | 0.84 | KMT2A (0.45) | HIF1AFFAR1FFAR4MAOB | |
| SCHEMBL9894740 | 0.84 | KMT2A (0.45) | HIF1AFFAR1FFAR4MAOB | |
| SCHEMBL9894739 | 0.84 | KMT2A (0.45) | HIF1AFFAR1FFAR4MAOB | |
| SCHEMBL7172808 | 0.84 | HIF1A (0.50) | HIF1A | |
| SCHEMBL7172810 | 0.84 | HIF1A (0.50) | HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6084120-A | ACTIVE AGAINST CHLOROQUINE-SENSITIVE PATIENTS AND AGAINST CHLOROQUINE-RESISTANT MALARIA PATHOGENS; PROPHYLAXIS AND TREATMENT; E.G., A 3 METHOXY-2-(2-(4-PHENYLBUTA-1,3-DIEN-1-YL)PHENYL)ACRYLIC ACID | HOFFMANN-LA ROCHE INC. (US) | 2000-07-04 | — | — | US | disclosed |