Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8169222 | 0.88 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL3301916 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL4554858 | 0.80 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL5683830 | 0.80 | KDM4E (0.59) | KDM4EALDH1A1HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL4467144 | 0.80 | KDM4E (0.73) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL3307771 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL3302729 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL3302759 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL3305912 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL858141 | 0.77 | KDM4E (0.65) | KDM4EALDH1A1HSD17B10LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008104175-A2 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2008-09-04 | — | — | WO | disclosed |