SCHEMBL8166172

SCHEMBL8166172

O=CCCCCC(Cl)(Cl)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.37
CYP1A2 P05177 1/20 0.35
KIF11 P52732 2/20 0.33
HIF1A Q16665 1/20 0.32
ADH1B P00325 1/20 0.31
ADH1C P00326 1/20 0.31
ADH1A P07327 1/20 0.31
ADH7 P40394 1/20 0.31
SIGMAR1 Q99720 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6682657 0.75 TSHR (0.41) TSHRKIF11SIGMAR1
SCHEMBL8166176 0.74 CYP1A2 (0.44) TSHRCYP1A2KIF11HIF1AALDH1A1
SCHEMBL7438264 0.74 TSHR (0.44) TSHRCYP1A2HIF1AADH1BADH1C
SCHEMBL8673280 0.73 HSP90AA1 (0.41) TSHRSIGMAR1
SCHEMBL6682924 0.73 HSP90AA1 (0.41) TSHRSIGMAR1
SCHEMBL6684931 0.73 HSP90AA1 (0.41) TSHRSIGMAR1
SCHEMBL24462797 0.73 KCNN4 (0.37) TSHRCYP1A2HIF1AADH1BADH1C
SCHEMBL6681947 0.72 TSHR (0.42) TSHRCYP1A2KIF11SIGMAR1
SCHEMBL8376477 0.72 TSHR (0.42) TSHRCYP1A2KIF11SIGMAR1
SCHEMBL22807007 0.72 TSHR (0.38) TSHRCYP1A2KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000075094-A2 METHOD FOR PRODUCING A HALOGENATED ACETOPHENONE ISHIHARA SANGYO KAISHA, LTD. (JP) 2000-12-14 WO disclosed