Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 15/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166975 | 0.91 | GRM2 (0.51) | GRM2DRD2DRD3 | |
| SCHEMBL2787435 | 0.86 | GRM2 (0.58) | GRM2 | |
| SCHEMBL8156100 | 0.83 | GRM2 (0.63) | GRM2DRD2DRD3 | |
| SCHEMBL8166648 | 0.83 | GRM2 (0.59) | GRM2 | |
| SCHEMBL8167879 | 0.79 | GRM2 (0.78) | GRM2DRD2DRD3 | |
| SCHEMBL2790183 | 0.78 | GRM2 (0.50) | GRM2 | |
| SCHEMBL2790392 | 0.77 | GRM2 (0.50) | GRM2 | |
| SCHEMBL8154462 | 0.73 | GRM2 (0.48) | GRM2OPRM1OPRK1DRD2DRD3 | |
| SCHEMBL1035638 | 0.73 | GRM2 (1.00) | GRM2 | |
| SCHEMBL8157903 | 0.72 | GRM2 (0.54) | GRM2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107479-A1 | 3-CYANO-4-(4-PHENYL-PIPERIDIN-1-YL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |