Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 17/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2832000 | 0.86 | GRM2 (0.68) | GRM2 | |
| SCHEMBL8167360 | 0.83 | GRM2 (0.48) | GRM2METAXL | |
| SCHEMBL30795030 | 0.76 | GRM2 (0.66) | GRM2 | |
| SCHEMBL2186047 | 0.76 | GRM2 (0.66) | GRM2 | |
| SCHEMBL2833898 | 0.74 | GRM2 (0.81) | GRM2 | |
| SCHEMBL30795860 | 0.73 | GRM2 (0.65) | GRM2 | |
| SCHEMBL2186805 | 0.73 | GRM2 (0.65) | GRM2 | |
| SCHEMBL2833971 | 0.72 | GRM2 (0.63) | GRM2 | |
| SCHEMBL2831898 | 0.71 | GRM2 (0.73) | GRM2 | |
| SCHEMBL8157229 | 0.69 | GRM2 (0.49) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107480-A1 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE MGLUR2 -RECEPTOR MODULATORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |