Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6025442 | 0.89 | GAA (0.57) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL6025444 | 0.89 | GAA (0.57) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL6157370 | 0.89 | GAA (0.57) | SMN1; SMN2MAPTNPC1RAB9AGAA | |
| SCHEMBL6191009 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTNPC1RAB9ACTDSP1 | |
| Biphenyl SCHEMBL27677322 | 0.77 | TSHR (0.52) | SMN1; SMN2MAPTNPC1RAB9ACTDSP1 | |
| SCHEMBL8165452 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL8165453 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL19309839 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTNPC1RAB9ACTDSP1 | |
| SCHEMBL8894615 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTNPC1RAB9ACTDSP1 | |
| SCHEMBL17973397 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTNPC1RAB9ACTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048852-A | BACTERICIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-04-11 | — | — | US | disclosed |
| EP-0900197-A1 | BETA-THIOPROPIONYL-AMINOACID DERIVATIVES AND THEIR USE AS BETA-LACTAMASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997030027-A1 | BETA-THIOPROPIONYL-AMINOACID DERIVATIVES AND THEIR USE AS BETA-LACTAMASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-21 | — | — | WO | disclosed |