Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.59 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL504310 | 0.87 | GRM5 (0.78) | GRM5ITGB3ITGA2BHRH3 | |
| SCHEMBL8160743 | 0.84 | HRH3 (0.57) | HRH3 | |
| SCHEMBL10190619 | 0.77 | GRM5 (0.78) | GRM5ITGB3ITGA2BHRH3 | |
| SCHEMBL504328 | 0.74 | GRM5 (1.00) | GRM5HRH3 | |
| SCHEMBL10190617 | 0.73 | GRM5 (0.93) | GRM5HRH3 | |
| SCHEMBL505037 | 0.73 | GRM5 (0.64) | GRM5ITGB3ITGA2BFFAR1 | |
| SCHEMBL504287 | 0.73 | GRM5 (1.00) | GRM5ITGB3ITGA2BHRH3 | |
| SCHEMBL10242676 | 0.70 | HRH3 (0.77) | HRH3 | |
| SCHEMBL503353 | 0.68 | GRM5 (1.00) | GRM5ITGB3ITGA2BHRH3 | |
| SCHEMBL504529 | 0.67 | GRM5 (1.00) | GRM5ITGB3ITGA2BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |