Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 9/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.73 |
| ▸ | HPGDS | O60760 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | HTR1A | P08908 | 1/20 | 0.71 |
| ▸ | MAOA | P21397 | 1/20 | 0.71 |
| ▸ | MAOB | P27338 | 1/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | MMP12 | P39900 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8150783 | 0.92 | CD274 (0.85) | CD274HPGDEPHX2ALDH1A1KDM4E | |
| SCHEMBL487964 | 0.92 | CD274 (0.84) | CD274HPGDEPHX2HPGDSALDH1A1 | |
| SCHEMBL16574185 | 0.88 | CD274 (0.79) | CD274HPGDALDH1A1HTR1AMAOA | |
| SCHEMBL4015612 | 0.87 | EPHX2 (0.82) | CD274HPGDEPHX2HPGDSALDH1A1 | |
| SCHEMBL14082516 | 0.87 | CD274 (0.77) | CD274HPGDHPGDSALDH1A1HTR1A | |
| SCHEMBL16462027 | 0.86 | CD274 (0.76) | CD274HPGDEPHX2HPGDSALDH1A1 | |
| SCHEMBL8150803 | 0.86 | HPGD (0.76) | CD274HPGDALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL3637852 | 0.86 | CD274 (0.75) | CD274HPGDEPHX2HPGDSALDH1A1 | |
| SCHEMBL6569882 | 0.85 | CD274 (0.77) | CD274HPGDEPHX2ALDH1A1HTR1A | |
| SCHEMBL4488493 | 0.85 | CD274 (0.77) | CD274HPGDEPHX2ALDH1A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042855-A1 | BENZAMIDE mGluR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | DEPARTMENT OF VETERANS AFFAIRS | 2009-02-12 | — | — | US | disclosed |
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042855-A1 | BENZAMIDE mGluR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM3 | CD274 2710/4885HPGD 3544/4885EPHX2 3401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.