Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | MLYCD | O95822 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4522241 | 0.91 | SMN1; SMN2 (0.76) | HDAC6HDAC3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8395225 | 0.91 | SMN1; SMN2 (0.76) | HDAC6HDAC3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25123079 | 0.91 | SMN1; SMN2 (0.76) | HDAC6HDAC3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8391563 | 0.89 | SMN1; SMN2 (0.73) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10722498 | 0.89 | HDAC6 (0.77) | HDAC6MEN1KMT2ASMN1; SMN2MLYCD | |
| SCHEMBL13096664 | 0.88 | MEN1 (0.76) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| Methyl Alcohol SCHEMBL11518093 | 0.88 | SMN1; SMN2 (0.72) | HDAC6MEN1KMT2ASMN1; SMN2MLYCD | |
| SCHEMBL1927570 | 0.87 | MEN1 (0.83) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8393362 | 0.85 | SMN1; SMN2 (0.68) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3642217 | 0.84 | SMN1; SMN2 (0.60) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042855-A1 | BENZAMIDE mGluR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | DEPARTMENT OF VETERANS AFFAIRS | 2009-02-12 | — | — | US | disclosed |
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042855-A1 | BENZAMIDE mGluR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | GRM5, GRIK5, GRM3 | HDAC6 1276/4885HDAC3 397/4885HDAC4 740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.