SCHEMBL8169481

SCHEMBL8169481

N#Cc1[c]c(Cl)c(F)nc1F

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17835446 0.77
SCHEMBL1361208 0.75
SCHEMBL1816433 0.69
SCHEMBL8168461 0.68
SCHEMBL10756272 0.62 MAPK1 (0.50)
SCHEMBL28123477 0.59 MEN1 (0.46)
SCHEMBL27981854 0.59 MEN1 (0.46)
SCHEMBL9115923 0.59 MEN1 (0.46)
SCHEMBL6442707 0.58 MEN1 (0.39)
SCHEMBL9735297 0.57 KHK (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0576123-B1 Watersoluble triphenodioxazine dye AVECIA LTD (GB) 2000-03-01 EP disclosed
US-5498712-A Triphenodioxazine dyes ZENECA LIMITED (GB) 1996-03-12 US disclosed
WO-1995021893-A1 AZO DYES ZENECA LIMITED (GB) 1995-08-17 WO disclosed
EP-0356014-B1 Reactive Dyes ZENECA LTD (GB) 1994-11-30 EP disclosed
WO-1994010345-A1 SKIN TREATMENT ZENECA LIMITED (GB) 1994-05-11 WO disclosed
EP-0576123-A1 Watersoluble triphenodioxazine dye ZENECA LIMITED (GB) 1993-12-29 EP disclosed
US-5189162-A Colorfast bright dyes for cellulose materials IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-02-23 US disclosed
US-5171852-A Dye cellulose textiles bright reddish blue shades IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-12-15 US disclosed
US-5126450-A Reactive dyes; blue shades on cotton IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-06-30 US disclosed
EP-0279122-B1 REACTIVE DYES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-06-10 EP disclosed
EP-0437920-A1 Reactive dyes ZENECA LIMITED (GB) 1991-07-24 EP disclosed
EP-0432879-A1 Reactive dyes ZENECA LIMITED (GB) 1991-06-19 EP disclosed
US-5019134-A Triphenodioxazines IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-05-28 US disclosed
EP-0356014-A1 Reactive Dyes ZENECA LIMITED (GB) 1990-02-28 EP disclosed
EP-0279122-A2 Reactive dyes IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-08-24 EP disclosed
EP-0138303-A1 Naphthalene sulphonic acids IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-04-24 EP disclosed